Biedrba "Apvienba HIV.LV" (ik dienu pl. 9 - 21)
apvieniba@apvienibahiv.lv

 
   
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27.08.2019


Vistara institta (ASV) profesors Luiss Montaners nolma uzzint, kpc daai Puertoriko sekss industrijas darbinieu ir negatvs HIV statuss, kaut vias biei maina partnerus un neizmanto prezervatvus. Eksperts izteica piemumu, ka biea spermas iedarbba rada prmaias makst, kas savukrt paaugstina imunitti pret HIV.
Profesors nolma pierdt o teoriju un veica eksperimentus ar makakas mttm. Pc 20 nedm eksperiment iesaisttajm makakm un kontroles grupai ievadja prtiu imndeficta vrusa SIV (radniecgs HIV) nelielas vaginls devas. Rezultt dzvnieki par 42% retk nek kontroles dzvnieki inficjs ar o slimbu.
Eksperts atzmja, ka sperma paaugstinja HIV supresjo faktora CCL5 lmeni makst un dzemdes kakl, k ar izraisja maksts audu sabiezanu.
Eksperti noskaidroja, ka, neraugoties uz to, ka risks tika samazints par 42%, t joprojm ir daudz mazka aizsardzba, nek spj nodroint prezervatvs.
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Source: Nature Communications | Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques | https://www.nature.com/articles/s41467-019-11814-5 |
<... Semen is the vehicle for virion dissemination in the female reproductive tract (FRT) in male-to-female HIV transmission. Recent data suggests that higher frequency semen exposure is associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, we use a non-human primate (NHP) model to show that repeated vaginal exposure to semen significantly reduces subsequent infection by repeated low-dose vaginal SIVmac251 challenge. Repeated semen exposures result in lower CCR5 expression in circulating CD4+ T-cells, as well as higher expression of Mx1 (in correlation with IFNε expression) and FoxP3 in the cervicovaginal mucosa, and increased infiltration of CD4+ T-cells. Establishing in vivo evidence of competing effects of semen on transmission impacts our basic understanding of what factors may determine HIV infectivity in humans. Our results clearly indicate that repeated semen exposure can profoundly modulate the FRT microenvironment, paradoxically promoting host resistance against HIV acquisition. ...>




 
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