Biedrba "Apvienba HIV.LV" (ik dienu pl. 9 - 21)


Vrusa apvalks nav sfrisks
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Kandas Albertas Universittes zintnieki, izmantojot matemtisko modelanu, noskaidrojui, ka HIV vrusa struktra atiras no ts, ko zintnieki ldz im uzskatja par viengo pareizo.
Tradicionlais modelis apgalvo, ka vruss HIV-1 atrodas sfriskaj apvalk. Kad tas infic veselu nu, apvalks saplst ar nas sieniu un vrusa RNS nokst n. Tau matemtisk modelana pardja da procesa neiespjambu.
Zintnieki apgalvo, ka vrusa HIV-1 apvalks vairk ldzins ziedlapim, kas atveras un izlai vrusa RNS. Ja modelis izrdsies pareizs, tas nozms, ka vars izstrdt zles, kas neaus atvrties ziedlapim, ttad, tiks novrsta cilvka nu inficans ar vrusu.
Kandas zintnieki iepriek jau zioja, ka ir atkljui vietas, kur HIV prlai antiretrovrusu terapiju, lai atgrieztos organism. Tas paver iespjas pilnb izrstties no HIV.
Source: Taking shape: Scientists propose new structure for shell of HIV-1 virus | | A newly proposed model for the shape of the HIV-1 viral shell may change how we understand the disease. |
<... The matrix shell of the HIV-1 virus may have a different shape than previously thought, and a newly proposed model has significant implications for understanding how the virus functions, according to a new study by University of Alberta scientists. 
The research suggests that the HIV-1 virus is housed within a spherical matrix shell. When it infects a healthy cell, the shell fuses to the outside of the target cell and then releases the viral capsid inside where it attacks the cell. 
Our new proposed structure for the HIV-1 virus has a very peculiar shape, almost like petals of a flower, said Sean Graves, instructor in the Department of Mathematical and Statistical Sciences and co-author on the study. A better structural knowledge of the matrix shell may help us understand the fusing and infection process. Graves is also coordinator of the Decima Robinson Support Centre, providing support to more than 1000 undergraduate students each term.
The research shows that the previous model used to describe the structure of the HIV-1 matrix shell was mathematically impossible and provides a viable alternative. While it is too early to anticipate whether the model will translate into new treatment for HIV, the research will help scientists to better understand and make predictions about the behaviour of the HIV-1 virus. Around the world, nearly 38 million people suffer from HIV or AIDS. 
Our contribution uses mathematical principles to help guide the scientific community in the right direction, added Marcelo Marcet-Palacios, adjunct professor of medicine in the Faculty of Medicine & Dentistry and co-author. If our model is correct, then we can begin investigating ways we could block or interrupt the mechanism of viral entry. For example, by using a medication that could cross-link the petals of the structure together to prevent the opening of the particle and thus stopping entry of the viral genome into the host cell. ...>


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